
This festive grilled cheese came together on a whim during a holiday brunch when I wanted to use up some leftover panettone and cranberry sauce. The result was a golden sandwich with melty Brie and ripples of sweet and tart fruit preserves—a treat halfway between dessert and a snack that has become a cold-weather favorite.
I first made this with my sister after we opened gifts one Christmas morning—now any time we see panettone in the store we buy it for this sandwich.
Ingredients
- Panettone: Four slices about one inch thick each this gently sweet bread brings a unique character to the sandwich look for one with a soft crumb and no excessive dryness
- Brie cheese: One hundred twenty grams sliced creamy and mild Brie melts beautifully and balances the fruit flavors opt for a wheel with a soft center
- Cranberry sauce: Two tablespoons this gives a bright tart kick chunky or smooth both work
- Cherry preserves: Two tablespoons for sweetness and a ruby hue use a quality preserve with real fruit pieces if possible
- Unsalted butter: Two tablespoons softened this ensures an even golden crust go for a rich European-style if you want an extra decadent touch
Instructions
- Prepare the panettone Slices:
- Cut the panettone into thick even slices about one inch each so they are sturdy enough for grilling
- Butter the Bread:
- Spread a thin layer of softened butter on one side of each panettone slice making sure to reach the edges for even browning
- Spread the Fruit Preserves:
- On the unbuttered side of two slices spread one tablespoon each of cranberry sauce and cherry preserves creating a vibrant layer that will nestle under the cheese
- Layer the Brie:
- Arrange the Brie slices over the fruit spreads on each prepared slice overlapping them for complete coverage so that every bite is oozy and rich
- Assemble the Sandwich:
- Top with the remaining panettone slices buttered side out pressing gently to form two sandwiches
- Heat the Pan:
- Place a nonstick skillet or griddle over medium-low heat allow it to fully preheat so the bread toasts gradually without burning
- Grill the Sandwiches:
- Gently place the sandwiches in the hot pan grill for three to four minutes per side pressing with a spatula until the panettone is deeply golden and the cheese has melted
- Rest and Slice:
- Transfer to a cutting board let rest for one minute then slice in halves or quarters and serve while the Brie is at its gooiest

One of my favorite parts of making this is watching how the Brie bubbles and ribbons of cherry run as you slice into the sandwich. My kids always beg to lick the spoon after I spread the cherry preserves.
Storage Tips
This sandwich is best hot from the pan but can be wrapped in foil and kept at room temperature for up to an hour. To reheat place in a toaster oven for three or four minutes until the bread crisps back up. Leftovers lose some crunch but are still tasty warmed on a skillet.
Ingredient Substitutions
No panettone on hand Use a sweet challah or rich brioche for a similar texture. Try Camembert or a mild creamy goat cheese if Brie is not available. If you dislike cherry preserves substitute with orange marmalade or fig spread for a special twist.
Serving Suggestions
Ideal for brunch or alongside a bowl of winter soup. Serve with a crisp greens salad dressed lightly with balsamic. Makes an indulgent finger sandwich for tea parties or holiday trays. I love this with a glass of sparkling wine.

Melted cheese and sweet fruit surrounded by crisp golden bread makes any day feel festive. This recipe will surprise and delight at your next brunch or cozy winter gathering.
Common Recipe Questions
- → Can I substitute the Brie with another cheese?
Yes, you can use Camembert or a soft goat cheese for a similar creamy texture and mild flavor.
- → What makes panettone suitable for grilling?
Panettone's slightly sweet, sturdy crumb toasts well, developing a crispy exterior while staying soft inside.
- → Are there ways to add more flavor?
Try adding arugula before grilling for peppery freshness or a sprinkle of sea salt after cooking for contrast.
- → Is this dish vegetarian-friendly?
Yes, as long as your panettone and cheese are made with vegetarian ingredients, it is suitable for vegetarians.
- → What sides pair well with this sandwich?
Serve alongside a light salad or a glass of sparkling wine for a festive meal experience.