One-Pot Cajun Chicken Alfredo

Featured in: Weeknight Dinners

This one-pot meal blends tender chicken with smoky Cajun spices and a rich Alfredo sauce, paired with orzo pasta. The process starts by sautéing seasoned chicken, followed by cooking onions, bell peppers, and garlic to build flavor. Orzo is toasted with spices before simmering in a mix of chicken broth, cream, and milk until tender. Chicken and fresh spinach are added back for a creamy finish with Parmesan cheese. Quick to prepare and perfect for a comforting weeknight dinner.

Updated on Sat, 22 Nov 2025 16:24:00 GMT
A steaming bowl of one-pot Cajun Chicken Alfredo Orzo, a creamy and flavorful meal. Save to Pinterest
A steaming bowl of one-pot Cajun Chicken Alfredo Orzo, a creamy and flavorful meal. | yummywithmia.com

A creamy, spicy, and comforting one-pot meal combining tender chicken, smoky Cajun spices, velvety Alfredo sauce, and orzo pasta for a quick weeknight dinner.

I first served this to my family on a busy weeknight and they loved how flavorful and easy it was to prepare.

Ingredients

  • Proteins: 2 large boneless skinless chicken breasts (about 450 g) cut into bite sized pieces
  • Vegetables: 1 small yellow onion finely chopped, 3 cloves garlic minced, 1 red bell pepper diced, 1 cup baby spinach roughly chopped (optional)
  • Pantry: 2 tablespoons olive oil, 1 1/2 cups (300 g) orzo pasta, 2 1/2 cups (600 ml) low sodium chicken broth, 1 cup (240 ml) heavy cream, 1/2 cup (120 ml) milk
  • Spices & Seasonings: 1 tablespoon Cajun seasoning (store bought or homemade), 1/2 teaspoon smoked paprika, 1/2 teaspoon salt or to taste, 1/4 teaspoon freshly ground black pepper, Pinch of cayenne pepper (optional for extra heat)
  • Cheeses: 3/4 cup (75 g) freshly grated Parmesan cheese
  • Garnish: Chopped fresh parsley, Extra Parmesan cheese

Instructions

Step 1:
Season the chicken pieces with half of the Cajun seasoning, salt, and pepper.
Step 2:
In a large, deep skillet or Dutch oven, heat olive oil over medium high heat. Add the chicken and sauté until browned and just cooked through, about 5 6 minutes. Remove chicken to a plate and set aside.
Step 3:
In the same pot, add onion and bell pepper. Sauté for 3 minutes until softened. Add garlic and cook for 1 minute more.
Step 4:
Stir in the orzo, smoked paprika, remaining Cajun seasoning, and cayenne pepper. Toast the orzo for 1 minute, stirring frequently.
Step 5:
Pour in the chicken broth, heavy cream, and milk. Stir well, scraping any browned bits from the bottom.
Step 6:
Bring to a gentle boil, then reduce heat to medium low. Cover and simmer for 10 12 minutes, stirring occasionally, until orzo is tender and most liquid is absorbed.
Step 7:
Return the chicken to the pot along with spinach (if using). Stir in Parmesan cheese until melted and creamy.
Step 8:
Taste and adjust seasoning. If sauce is too thick, add a splash more milk or broth.
Step 9:
Serve hot, garnished with parsley and extra Parmesan.
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| yummywithmia.com

This dish quickly became a family favorite around our dinner table, bringing warmth and comfort on even the busiest nights.

Notes

For a lighter version, use half and half instead of heavy cream. Swap chicken with shrimp or smoked sausage for variation. Add mushrooms or peas for extra vegetables. Serve with crusty bread or a green salad.

Required Tools

Large deep skillet or Dutch oven with lid, Cutting board and knife, Wooden spoon or spatula, Measuring cups and spoons, Grater (for Parmesan)

Nutritional Information

Calories 570, Total Fat 27 g, Carbohydrates 48 g, Protein 37 g per serving

Tender chicken and spicy Cajun flavors combined in this easy one-pot Cajun Chicken Alfredo Orzo. Save to Pinterest
Tender chicken and spicy Cajun flavors combined in this easy one-pot Cajun Chicken Alfredo Orzo. | yummywithmia.com

This flavorful dish comes together swiftly and makes a satisfying meal any night of the week.

Common Recipe Questions

How do I keep the chicken tender?

Brown the chicken pieces over medium-high heat until just cooked through, avoiding overcooking to retain juiciness.

Can I substitute orzo with another pasta?

Yes, small pasta shapes like acini di pepe or couscous work well, adjusting cooking times accordingly.

What does Cajun seasoning add?

Cajun seasoning provides a smoky, spicy kick that complements the creamy Alfredo sauce beautifully.

Is it possible to include more vegetables?

Absolutely! Adding mushrooms, peas, or extra spinach enhances flavor and nutrition without altering the dish's essence.

How do I adjust the sauce consistency?

If the sauce becomes too thick, simply stir in a splash of milk or broth to reach desired creaminess.

One-Pot Cajun Chicken Alfredo

Creamy and spicy chicken with Cajun spices, Alfredo, and orzo cooked all in one dish.

Prep Time
15 minutes
Cooking Duration
25 minutes
Overall Time
40 minutes
Created by Mia

Recipe Type Weeknight Dinners

Skill Level Easy

Culinary Origin American, Cajun-Inspired

Total Output 4 Portion Size

Dietary Preferences None specified

What You'll Need

Proteins

01 2 large boneless, skinless chicken breasts, cut into bite-sized pieces

Vegetables

01 1 small yellow onion, finely chopped
02 3 cloves garlic, minced
03 1 red bell pepper, diced
04 1 cup baby spinach, roughly chopped (optional)

Pantry

01 2 tablespoons olive oil
02 1 1/2 cups orzo pasta
03 2 1/2 cups low-sodium chicken broth
04 1 cup heavy cream
05 1/2 cup milk

Spices & Seasonings

01 1 tablespoon Cajun seasoning
02 1/2 teaspoon smoked paprika
03 1/2 teaspoon salt, or to taste
04 1/4 teaspoon freshly ground black pepper
05 Pinch of cayenne pepper (optional)

Cheeses

01 3/4 cup freshly grated Parmesan cheese

Garnish

01 Chopped fresh parsley
02 Extra Parmesan cheese

Steps to Follow

Step 01

Season chicken: Combine half the Cajun seasoning, salt, and black pepper with chicken pieces and set aside.

Step 02

Brown chicken: Heat olive oil in a large skillet or Dutch oven over medium-high heat. Add chicken and cook until browned and just cooked through, about 5 to 6 minutes. Remove and set aside.

Step 03

Sauté vegetables: Using the same pot, sauté onion and red bell pepper for 3 minutes until softened. Add garlic and cook for an additional minute.

Step 04

Toast orzo and spices: Add orzo pasta, smoked paprika, remaining Cajun seasoning, and optional cayenne pepper. Stir frequently and toast for 1 minute.

Step 05

Add liquids and simmer: Pour in chicken broth, heavy cream, and milk, scraping any browned bits from the bottom. Bring to a gentle boil, then reduce heat to medium-low. Cover and simmer for 10 to 12 minutes, stirring occasionally, until orzo is tender and most liquid is absorbed.

Step 06

Incorporate chicken and spinach: Return the cooked chicken to the pot along with baby spinach if using. Stir in Parmesan cheese until fully melted and the sauce is creamy.

Step 07

Adjust seasoning and serve: Taste and adjust seasonings as necessary. If sauce is too thick, add a splash of milk or broth. Serve immediately garnished with fresh parsley and additional Parmesan cheese.

Tools Required

  • Large deep skillet or Dutch oven with lid
  • Cutting board and knife
  • Wooden spoon or spatula
  • Measuring cups and spoons
  • Grater for Parmesan cheese

Allergy Warnings

Please review individual ingredients for potential allergens and reach out to a healthcare professional if unsure.
  • Contains dairy (cream, milk, Parmesan), wheat (orzo), and possible celery in broth.

Nutritional Info (per serving)

These details are for reference only and shouldn't replace professional medical consultation.
  • Calories Count: 570
  • Fats: 27 grams
  • Carbohydrates: 48 grams
  • Proteins: 37 grams