High Protein Italian Beef Pasta Bake

Featured in: Weeknight Dinners

This High Protein Italian Beef and Pasta Bake combines lean ground beef, whole wheat pasta, and fresh vegetables in a savory tomato-based sauce, finished with a golden cheese topping. Perfect for meal prep or family dinners, each serving delivers 33g of protein and 370 calories. The pizza-inspired flavors come from oregano, basil, and optional turkey pepperoni, while mushrooms, bell peppers, and spinach add nutritional value. Simply brown the beef, sauté the vegetables, simmer with crushed tomatoes and herbs, combine with cooked pasta, transfer to a baking dish, top with mozzarella and Parmesan, then bake until bubbly in just 20 minutes.

Updated on Tue, 20 Jan 2026 13:10:00 GMT
Golden-brown, melty cheese bubbling over a hearty High Protein Italian Beef and Pasta Bake, with a spoonful ready to serve. Save to Pinterest
Golden-brown, melty cheese bubbling over a hearty High Protein Italian Beef and Pasta Bake, with a spoonful ready to serve. | yummywithmia.com

The smell of oregano and browning beef always takes me straight back to weeknight chaos, when I needed something filling that wouldn't wreck my macros. I started tinkering with this bake after a gym buddy swore by meal prep casseroles, and I wanted the comfort of pizza without the carb coma. Whole wheat penne, lean beef, and a mountain of veggies became my compromise between nostalgia and nutrition. The first time I pulled it from the oven, bubbling and golden, I knew I'd cracked the code. It's been my Sunday ritual ever since.

I made this for a potluck once, and my friend who lifts religiously asked for the recipe before she even finished her plate. She couldn't believe it was under 400 calories because the cheese pull was so satisfying. I watched her go back for seconds, then thirds, and I felt quietly smug. That night, I realized this wasn't just fuel, it was comfort food that happened to fit my goals. It's rare to find a dish that makes everyone happy, from the macro counters to the picky kids.

Ingredients

  • Whole wheat penne or rotini (300 g): The nutty flavor and extra fiber keep you satisfied longer, and the sturdy shape holds up beautifully under all that sauce and cheese without turning mushy.
  • Extra-lean ground beef (450 g): This is your protein powerhouse, and choosing extra-lean means you skip the greasy puddle at the bottom of the pan while still getting that rich, meaty flavor.
  • Onion (1 medium, diced): It adds sweetness and depth to the sauce, and I've learned that dicing it small helps it melt into the background for anyone who claims they don't like onions.
  • Garlic (2 cloves, minced): Fresh garlic makes the kitchen smell like an Italian grandmother's house, and it's worth the sticky fingers to mince it yourself instead of using jarred.
  • Red bell pepper (1, diced): The sweetness balances the acidity of the tomatoes, plus the bright color makes the whole dish look more vibrant and alive.
  • Mushrooms (100 g, sliced): They add an earthy, umami richness that makes the sauce taste more complex, and they soak up all the flavors like little flavor sponges.
  • Baby spinach (100 g): It wilts down to almost nothing, so you can pack in a ton of greens without anyone noticing, and it boosts the nutrition without changing the taste.
  • Crushed tomatoes (700 ml): The base of your sauce, and I prefer crushed over diced because it clings to the pasta better and creates a smoother, more cohesive dish.
  • Tomato paste (2 tbsp): This little addition deepens the tomato flavor and gives the sauce body, making it taste like it simmered for hours even though it didn't.
  • Dried oregano (1 tsp): It's the signature Italian herb that makes everything taste like pizza, and a little goes a long way in building that classic flavor profile.
  • Dried basil (1 tsp): It adds a sweet, slightly peppery note that rounds out the oregano and makes the sauce taste complete.
  • Chili flakes (½ tsp, optional): A tiny kick of heat wakes up your taste buds and cuts through the richness of the cheese, but you can skip it if you're feeding sensitive palates.
  • Part-skim mozzarella (150 g, shredded): It melts into gooey, stretchy perfection without drowning the dish in fat, and it's the cheese pull we're all here for.
  • Grated Parmesan (30 g): A salty, nutty finishing touch that adds complexity and a gorgeous golden crust on top.
  • Turkey pepperoni (30 g, optional): It brings that unmistakable pizza vibe without the grease, and the edges crisp up in the oven for a satisfying texture contrast.
  • Fresh basil (for garnish, optional): A handful of torn leaves on top makes it look restaurant-worthy and adds a burst of fresh, aromatic flavor right before you dig in.

Instructions

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Preheat and prep:
Set your oven to 200°C (400°F) so it's ready when you are. This gives you time to get everything else done without waiting around.
Cook the pasta:
Boil the whole wheat penne in well-salted water until it's just al dente, with a little bite left in the center. Drain it and set it aside, knowing it will finish cooking in the oven.
Brown the beef:
Heat a large nonstick skillet over medium heat and cook the ground beef, breaking it into crumbles with your spoon until it's browned all over. If any fat pools at the bottom, drain it off so the sauce stays light.
Sauté the vegetables:
Toss in the onion, garlic, bell pepper, and mushrooms, stirring them around for 5 to 7 minutes until they soften and smell amazing. The kitchen will start to smell like a real Italian kitchen at this point.
Wilt the spinach:
Add the baby spinach and stir it in, watching it shrink down in about a minute. It's almost magical how much green disappears into the pan.
Build the sauce:
Pour in the crushed tomatoes and tomato paste, then sprinkle in the oregano, basil, chili flakes, salt, and pepper. Let it simmer for 5 minutes, stirring occasionally, so all the flavors can get to know each other.
Combine pasta and sauce:
Dump the cooked pasta into the skillet and stir everything together until every piece is coated in that rich, beefy tomato sauce. It should look hearty and inviting.
Transfer to baking dish:
Lightly grease a 23x33 cm (9x13 inch) baking dish and spread the pasta mixture evenly across the bottom. Try to make it level so the cheese melts evenly.
Top with cheese:
Sprinkle the mozzarella and Parmesan over the top, then lay the turkey pepperoni slices on top if you're using them. It should look like a pasta-pizza hybrid.
Bake until bubbly:
Slide the dish into the oven and bake for 20 minutes, until the cheese is melted, golden, and bubbling around the edges. The smell alone will have everyone hovering in the kitchen.
Garnish and serve:
Let it cool for a couple of minutes, then scatter fresh basil over the top if you have it. Serve it hot and watch it disappear.
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Close-up of the High Protein Italian Beef and Pasta Bake, revealing savory ground beef and tender vegetables in every cheesy bite. Save to Pinterest
Close-up of the High Protein Italian Beef and Pasta Bake, revealing savory ground beef and tender vegetables in every cheesy bite. | yummywithmia.com

One Sunday, I prepped two of these bakes back to back and portioned them into containers for the week. My roommate walked in, saw the lineup in the fridge, and asked if I was opening a restaurant. I laughed, but honestly, having grab-and-go lunches that tasted this good made the whole week feel easier. There's something quietly powerful about knowing you've got your meals handled, especially when they're this satisfying. That week, I didn't cave to the vending machine once.

Making It Your Own

This bake is forgiving and flexible, so don't be afraid to play around. I've stirred in low-fat cottage cheese for extra creaminess and protein, swapped the pasta for chickpea or lentil varieties when I wanted even more protein, and loaded in zucchini or black olives when I had them on hand. One time I added a layer of ricotta in the middle, and it turned into a lasagna-adjacent masterpiece. The base recipe is solid, but it's also a canvas for whatever your fridge is offering.

Storing and Reheating

Leftovers keep beautifully in the fridge for up to four days, tightly covered. I usually portion it into individual containers so I can grab one on my way out the door. Reheat in the microwave for a couple of minutes, stirring halfway through, or pop a portion back in the oven at 180°C (350°F) until warmed through. If you're freezing it, let it cool completely first, then wrap it well and freeze for up to three months. Thaw overnight in the fridge before reheating, and it'll taste just as good as the day you made it.

Serving Suggestions

This bake is hearty enough to stand on its own, but I love pairing it with a crisp green salad dressed simply with lemon and olive oil. Garlic bread feels like overkill to me now, but if you want it, go for a thin slice of whole grain toast rubbed with a garlic clove. Sometimes I'll throw together a quick cucumber and tomato salad with red onion and a splash of vinegar, and it cuts through the richness perfectly.

  • A handful of arugula on the side adds a peppery bite that wakes up your palate between forkfuls.
  • Roasted broccoli or green beans make excellent veggie companions if you want even more fiber.
  • A glass of sparkling water with lemon feels more refreshing than soda and keeps the meal feeling light.
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Fresh basil garnishes a slice of High Protein Italian Beef and Pasta Bake, served hot from the oven for a family dinner. Save to Pinterest
Fresh basil garnishes a slice of High Protein Italian Beef and Pasta Bake, served hot from the oven for a family dinner. | yummywithmia.com

This bake has become my go-to when I need something reliable, nourishing, and actually delicious. It proves you don't have to choose between eating well and eating food that makes you happy.

Common Recipe Questions

Can I make this ahead and freeze it?

Yes, you can prepare the entire bake through step 8, cover it tightly with plastic wrap and foil, and freeze for up to 3 months. Thaw overnight in the refrigerator before baking, adding 5-10 minutes extra baking time if needed.

How do I increase the protein content further?

Stir 200g of low-fat cottage cheese or ricotta into the pasta mixture before transferring to the baking dish. Alternatively, use chickpea or lentil pasta instead of whole wheat pasta for significantly higher protein content.

Is this suitable for gluten-free diets?

The standard version contains wheat pasta. Simply substitute with gluten-free pasta cooked al dente, and verify that all other ingredients including tomato paste and spices are certified gluten-free.

What vegetables can I substitute or add?

Roasted zucchini, eggplant, black olives, sun-dried tomatoes, or broccoli work beautifully. Add diced vegetables of your choice to the sauté step, keeping in mind that softer vegetables may need less cooking time.

How should I store leftovers?

Cover and refrigerate in an airtight container for up to 4 days. Reheat individual portions in the microwave at 70% power for 2-3 minutes, or cover and warm in a 180°C oven for 15-20 minutes until heated through.

Can I use different types of cheese?

Absolutely. Ricotta, pecorino romano, or a combination of cheeses work well. For lower fat options, use part-skim varieties, and adjust quantities based on your preferred cheese-to-pasta ratio and fat content goals.

High Protein Italian Beef Pasta Bake

Hearty pasta bake with lean ground beef, fresh vegetables, and melted cheese. Pizza-inspired flavors in a satisfying 50-minute meal.

Prep Time
20 minutes
Cooking Duration
30 minutes
Overall Time
50 minutes
Created by Mia

Recipe Type Weeknight Dinners

Skill Level Easy

Culinary Origin Italian-American

Total Output 6 Portion Size

Dietary Preferences None specified

What You'll Need

Pasta

01 10.5 oz whole wheat penne or rotini pasta

Beef & Vegetables

01 1 lb extra-lean ground beef
02 1 medium onion, diced
03 2 cloves garlic, minced
04 1 red bell pepper, diced
05 3.5 oz mushrooms, sliced
06 3.5 oz baby spinach

Sauce

01 24 fl oz canned crushed tomatoes
02 2 tablespoons tomato paste
03 1 teaspoon dried oregano
04 1 teaspoon dried basil
05 0.5 teaspoon chili flakes, optional
06 Salt and freshly ground black pepper to taste

Cheese & Toppings

01 5 oz part-skim mozzarella cheese, shredded
02 1 oz grated Parmesan cheese
03 1 oz turkey pepperoni slices, optional
04 Fresh basil for garnish, optional

Steps to Follow

Step 01

Preheat oven: Preheat oven to 400°F.

Step 02

Cook pasta: Cook pasta in a large pot of boiling salted water until al dente. Drain and set aside.

Step 03

Brown ground beef: In a large nonstick skillet over medium heat, cook the ground beef until browned, breaking it up as it cooks. Drain excess fat if needed.

Step 04

Sauté vegetables: Add onion, garlic, bell pepper, and mushrooms to the skillet. Sauté for 5 to 7 minutes until softened.

Step 05

Wilt spinach: Stir in spinach and cook until wilted, approximately 1 minute.

Step 06

Build sauce: Add crushed tomatoes, tomato paste, oregano, basil, chili flakes, salt, and pepper. Simmer for 5 minutes to allow flavors to meld.

Step 07

Combine pasta and sauce: Combine the cooked pasta with the beef and vegetable sauce mixture.

Step 08

Transfer to baking dish: Transfer the mixture to a lightly greased 9x13 inch baking dish.

Step 09

Add cheese topping: Sprinkle mozzarella and Parmesan evenly over the top. Arrange turkey pepperoni slices if using.

Step 10

Bake until bubbly: Bake for 20 minutes, until cheese is melted and bubbly.

Step 11

Garnish and serve: Garnish with fresh basil before serving if desired.

Tools Required

  • Large pot
  • Large nonstick skillet
  • 9x13 inch baking dish
  • Mixing spoon
  • Cheese grater

Allergy Warnings

Please review individual ingredients for potential allergens and reach out to a healthcare professional if unsure.
  • Contains wheat from pasta
  • Contains milk from cheese and optional cottage or ricotta cheese
  • May contain soy from processed meats or cheese, check ingredient labels

Nutritional Info (per serving)

These details are for reference only and shouldn't replace professional medical consultation.
  • Calories Count: 370
  • Fats: 11 grams
  • Carbohydrates: 37 grams
  • Proteins: 33 grams