01 - Preheat oven to 190°C (375°F) and grease a 9x13 inch baking dish.
02 - Bring a large pot of salted water to a boil. Cook macaroni according to package instructions until al dente. Drain well and set aside.
03 - In a large saucepan, melt butter over medium heat. Add flour and whisk continuously for 1-2 minutes to form a smooth roux.
04 - Gradually whisk in milk and cream. Continue cooking, stirring frequently, until the sauce thickens, about 4-5 minutes.
05 - Add garlic powder, onion powder, salt, and pepper to the sauce, stirring to incorporate.
06 - Reduce heat to low and add cheddar, mozzarella, and parmesan cheeses. Stir until completely melted and sauce is smooth.
07 - Add the cooked macaroni to the cheese sauce and fold until all pasta is evenly coated.
08 - Pour the macaroni and cheese mixture into the prepared baking dish, spreading evenly.
09 - In a small bowl, combine panko breadcrumbs with melted butter and sprinkle evenly over the macaroni and cheese.
10 - Bake in preheated oven for 20-25 minutes until bubbly and golden brown on top.
11 - Allow to rest for 5 minutes before serving to set the sauce.