01 - Rinse and pat dry the catfish fillets.
02 - In a large bowl or zip-top bag, combine buttermilk, hot sauce, salt, and pepper. Submerge fillets and refrigerate for at least 1 hour.
03 - In a shallow dish, mix cornmeal, flour, garlic powder, onion powder, paprika, cayenne, salt, and pepper.
04 - Heat oil in a deep skillet or fryer to 175°C (350°F).
05 - Remove fillets from marinade, allowing excess to drip off. Dredge in cornmeal mixture, pressing gently to coat evenly.
06 - Fry fillets in batches for 4–5 minutes per side until golden brown and cooked through. Drain on paper towels.
07 - Serve hot with lemon wedges and optional parsley garnish.